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ATG7 Rabbit rabbit pAb

CAT: 0855-ES20825-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20825-01Size:50 µL
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Background
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Description
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
UniProt
O95352
Swiss Prot
O95352
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein of ATG7
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300, WB 1:500-2000
Molecular Weight
78kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
78kD
Fragment
IgG
Subcellular Location
Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
Other Product Names
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein)
Gene ID (Human)
10533

UniProtKB · O95352

Ubiquitin-like modifier-activating enzyme ATG7

ATG7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95352
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATG7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4E170, E9PB95, Q7L8L0, Q9BWP2, Q9UFH4
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

AutophagyBiological rhythmsProtein transportTransportUbl conjugation pathway

Cellular component

Cytoplasm

Disease

Disease variantNeurodegeneration

Technical term

Proteomics identificationReference proteome

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