Products for Research Use Only
RegisterLogin

JAM3 rabbit pAb

CAT: 0855-ES9186-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES9186-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq
Description
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants. [provided by RefSeq,
UniProt
Q9BX67
Swiss Prot
Q9BX67
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Target
JAM3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
34kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
34kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell junction . Cell junction, desmosome . Cell junction, tight junction . Detected in the acrosome region in developing spermatids (By similarity) . In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813) . Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945) . .; [Soluble form of JAM-C]: Secreted .
Gene ID (Human)
83700

Related Products

CatalogName
ES4209-01JAM-A rabbit pAb
ES3845-01JAM-B rabbit pAb
ELK6594-01Human JAM3 (Junctional Adhesion Molecule 3) ELISA Kit
ES4666-01RAB3IP rabbit pAb
ELK6594MS-01Human JAM3 (Junctional Adhesion Molecule 3) Microsample ELISA Kit
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb

Alternative Products

CatalogName
E2164303JAM3 Rabbit pAb
APR21496N-01JAM3 Rabbit pAb (APR21496N)
GTR18680987-01JAM3 Rabbit Polyclonal Antibody
GTR18053464-01JAM3 rabbit pAb Antibody
PA8569-01Rabbit Anti-Human JAM3 pAb
GTR18369931JAM3 Rabbit Polyclonal Antibody (Biotin)
GTR18369930JAM3 Rabbit Polyclonal Antibody (FITC)
GTR18369929JAM3 Rabbit Polyclonal Antibody (HRP)
PAV1927Rabbit Anti-JAM3 Polyclonal Antibody
TA339629Junctional Adhesion Molecule C (JAM3) Rabbit Polyclonal Antibody

Popular Products