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WIPI2 Rabbit rabbit pAb

CAT: 0855-ES20596-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20596-01Size:50 µL
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Background
WD repeat domain, phosphoinositide interacting 2 (WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]) .[supplied by OMIM, Mar 2008]
Description
WD repeat domain, phosphoinositide interacting 2 (WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al. 2004 [PubMed 15602573]). [supplied by OMIM, Mar 2008],
UniProt
Q9Y4P8
Swiss Prot
Q9Y4P8
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein of WIPI2
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300
Molecular Weight
49kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
49kD
Fragment
IgG
Subcellular Location
Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .
Other Product Names
WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2; WIPI49-like protein 2)
Gene ID (Human)
26100

UniProtKB · Q9Y4P8

WD repeat domain phosphoinositide-interacting protein 2

WIPI2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y4P8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
WIPI2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
WIPI-2
EC number
—
Processing
—
Secondary accessions
B3KNC2, Q5MNZ8, Q6FI96, Q75L50, Q96IE4, Q9Y364
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Autophagy

Disease

Disease variantIntellectual disability

Ligand

Lipid-binding

Cellular component

Membrane

PTM

Phosphoprotein

Domain

RepeatWD repeat

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