4β-Hydroxycholesterol-d5

• UNSPSC Description:

  4β-Hydroxycholesterol-d5 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Field of Research:

  Metabolic Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@](C([2H])([2H])C[C@]1(C2=C([2H])C[C@@]3([C@@]1(CC[C@]4([C@]3(CC[C@@]4([C@@H](CCCC(C)C)C)[H])[H])C)[H])[H])C)([2H])[C@]2([2H])O

• Molecular Weight:

  407.68

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Granchi C,et al. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported