ML 190

• UNSPSC Description:

  ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].

• Target Antigen:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ml-190.html

• Purity:

  98.2

• Solubility:

  DMSO : 9.77 mg/mL (ultrasonic;warming)

• Smiles:

  O=C1C2=CC=CN2C3=C(C)C=CN=C3N1CC(NCCCN4CCN(CC4)C5=CC=C(C=C5)OC)=O

• Molecular Weight:

  488.58

• References & Citations:

  [1]Frankowski KJ, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci. 2012;3(3):221-236.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1355244-02-8