ML 190

• Description :

  ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].

• CAS Number :

  [1355244-02-8]

• UNSPSC :

  12352005

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ml-190.html

• Purity :

  99.60

• Solubility :

  DMSO : 9.77 mg/mL (ultrasonic; warming)

• Smiles :

  O=C1C2=CC=CN2C3=C(C)C=CN=C3N1CC(NCCCN4CCN(CC4)C5=CC=C(C=C5)OC)=O

• Molecular Formula :

  C27H32N6O3

• Molecular Weight :

  488.58

• References & Citations :

  [1]Frankowski KJ, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci. 2012;3 (3) :221-236.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  κ Opioid Receptor/KOR