MF-438

• Description :

  MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Stearoyl-CoA Desaturase (SCD)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/mf-438.html

• Purity :

  99.92

• Solubility :

  DMF : 50 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  FC(C1=CC=CC=C1OC2CCN(C3=NN=C(C4=NN=C(C)S4)C=C3)CC2)(F)F

• Molecular Formula :

  C19H18F3N5OS

• Molecular Weight :

  421.44

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438) . Bioorg Med Chem Lett. 2010 Jan 15;20 (2) :499-502.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [921605-87-0]