AL-438

CAT: 0804-HY-114154Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-114154Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].
CAS Number
[239066-73-0]
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/al-438.html
Solubility
10 mM in DMSO
Smiles
C=CCC1OC2=CC=CC(OC)=C2C3=C1C4=C(NC(C)(C)C=C4C)C=C3
Molecular Formula
C23H25NO2
Molecular Weight
347.45
References & Citations
[1]Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264 (1-2) :164-70.|[2]Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17 (5) :860-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P991193-01NGM-438
HY-15822-01MF-438
HY-123486HS-438
HY-W952982CRBN ligand-438
HY-P10252HIV gp120 (421-438)
HY-15709-01AL 082D06
HY-125150AL-3138
HY-167011Al-28
HY-146009AL-470
HY-108645-01AL 8697

Alternative Products

CatalogName
MF-0062444-01AL-438
M22502-01MF-438
MBS3601071-01TAK-438
MBS5813578BAY-438
MF-0101388-01NGM-438
MF-0047353-01HS-438
MBS132349-01TAK 438

Popular Products