RTIOXA-43

• Description :

  RTIOXA-43 is a orexin receptor agonist with EC50s of 24 nM and 24 nM for OX2 and OX1 receptors, respectively[1].

• UNSPSC :

  12352005

• Target :

  Orexin Receptor (OX Receptor)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/rtioxa-43.html

• Purity :

  99.94

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC(C2=CC=C(OC)C(S(=O)(NC3=CC=CC(NCCNC(C4=CC=CC(C)=C4)=O)=C3)=O)=C2)=CC=C1)N(C)CC5=CC=NC=C5

• Molecular Formula :

  C37H37N5O5S

• Molecular Weight :

  663.79

• References & Citations :

  [1]Yanan Zhang, et al. Arylsulfoxamides as orexin receptor agonists. WO2022187231A1. |[2]Kotz, Catherine, et al. Small Molecule Orexin Agonists Enhance Physical Activity, Cognition and Sleep Quality in Aged Mice. Obesity; Silver Spring Vol. 29, (Dec 2021) : 163.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  OX1 Receptor; OX2 Receptor

• CAS Number :

  [2832067-72-6]