INI-43

• Description:

  INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H315

• Target:

  AP-1; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ini-43.html

• Purity:

  99.28

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  NC1=C(C2=NC3=CC=CC=C3N=C2N1CCCN(C)C)C4=NC5=CC=CC=C5N4

• Molecular Formula:

  C22H23N7

• Molecular Weight:

  385.46

• Precautions:

  H315

• References & Citations:

  [1]F J Stanfield, et al. The antiviral activity of caprochlorone. Proc Soc Exp Biol Med. 1967 May;125 (1) :297-303.|[2]Chi RA, et al. Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer. BMC Cancer. 2021 Feb 2;21 (1) :106.|[3]van der Watt PJ, et al. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15 (4) :560-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [881046-01-1]