HPK1-IN-43

• Description :

  HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ) . HPK1-IN-43 can be used in cancer research[1].

• UNSPSC :

  12352005

• Target :

  IFNAR; Interleukin Related; MAP4K

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hpk1-in-43.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1

• Molecular Formula :

  C26H25F3N6O2

• Molecular Weight :

  510.51

• References & Citations :

  [1]Qiu X, et al. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur J Med Chem. 2024 Apr 5;269:116310.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-2; MAP4K1/HPK1