HPK1-IN-43

• UNSPSC Description:

  HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research[1].

• Target Antigen:

  IFNAR; Interleukin Related; MAP4K

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hpk1-in-43.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1

• Molecular Weight:

  510.51

• References & Citations:

  [1]Qiu X, et al. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur J Med Chem. 2024 Apr 5;269:116310.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported