NRX-2663

• Description:

  NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 μM and a Kd of 54.8 nM[1].

• UNSPSC:

  12352005

• Target:

  E1/E2/E3 Enzyme; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nrx-2663.html

• Concentration:

  10mM

• Purity:

  98.96

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O

• Molecular Formula:

  C20H13F3N2O5

• Molecular Weight:

  418.32

• References & Citations:

  [1]Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10 (1) :1402.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2763260-34-8]