NRX-204647

• Description:

  NRX-204647 is a potent activator of retinoic acid nuclear (RAR) with higher specificity than that to RAR and RAR. NRX-204647 can inhibit bone formation. NRX-204647 significantly reduces bone volume/tissue volume (BV/TV) . NRX-204647 can be studied in anti-cancer research[1][2].

• UNSPSC:

  12352005

• Target:

  RAR/RXR

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C (C1=CC=C (C=C1) /C=C/C (C2=CC=C3C (C) (CCC (C) (C3=C2) C) C) =N/O) O

• Molecular Formula:

  C24H27NO3

• Molecular Weight:

  377.48

• References & Citations:

  [1]Uchibe, K., et al., (2017) . Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35 (5), 1096-1105.|[2]Garcia, S. A., et al., (2020) . Understanding the Action of RARγ Agonists on Human Osteochondroma Explants. International journal of molecular sciences, 21 (8), 2686.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1351452-80-6