Products for Research Use Only
RegisterLogin

NRX-103094

CAT: 0804-HY-141449-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-141449-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM[1].
CAS Number
2763260-36-0
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Molecular Glues; β-catenin
Type
Reference compound
Related Pathways
PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nrx-103094.html
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)=O
Molecular Formula
C20H11Cl2F3N2O4S
Molecular Weight
503.28
Precautions
H302, H312, H332
References & Citations
[1]Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10 (1) :1402.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-141450-01NRX-103095
HY-111760-01NRX-252262
HY-141448-01NRX-2663
HY-144982-01NRX-1532
HY-111836-01NRX-252114
HY-144984-01NRX-1933
HY-117227NRX-204647
HY-153357-01NRX-0492
HY-101382-01GR 103691
HY-P2595SKF 103784

Alternative Products

CatalogName
M35719-01NRX-103094
BA9145-5NRX-2663
BA9146-5NRX-103095
BA9140-5.1NRX-252262
BA8837-10NRX-0492
7990/25NRX 252114
MBS5813449NRX-204647
SAB408-01Nrx Antibody
BA9143-5NRX-252114
GTR19187389-01NRX-1532

Popular Products