NLX-266

• Description:

  NLX-266 is an orally active ERK1/2-biased 5-HT1A receptor agonist. NLX-266 can be used in the study of Parkinson's disease[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC(F)=C3)(F)CC2

• Molecular Formula:

  C20H21ClF3N3O2

• Molecular Weight:

  427.85

• References & Citations:

  [1]Sniecikowska J, et al. Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity. J Med Chem. 2025 May 8;68 (9) :9706-9722.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor

• CAS Number:

  2170564-20-0