NLX-266

• Description :

  NLX-266 is an orally active ERK1/2-biased 5-HT1A receptor agonist. NLX-266 can be used in the study of Parkinson's disease[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC(F)=C3)(F)CC2

• Molecular Formula :

  C20H21ClF3N3O2

• Molecular Weight :

  427.85

• References & Citations :

  [1]Sniecikowska J, et al. Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity. J Med Chem. 2025 May 8;68 (9) :9706-9722.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor

• CAS Number :

  [2170564-20-0]