NRX-252114

• Description :

  NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Molecular Glues; β-catenin

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nrx-252114.html

• Purity :

  99.43

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  N#CC1=CC=CC2=C1CN(C(C3=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)NC3=O)=O)C2

• Molecular Formula :

  C22H12Cl2F3N3O2S

• Molecular Weight :

  510.32

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10 (1) :1402.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2763260-39-3]