NRX-1933

CAT: 0804-HY-144984-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-144984-01Size:5 mg
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Description
NRX-1933 is a type of molecular glue. NRX-1933 is a β-catenin:β-TrCP interaction enhancer for the development of small molecule degraders. NRX-1933 promotes the ubiquitination of mutated β-Catenin, leading to degradation. NRX-1933 can be applied to tumor research on abnormal activation of Wnt/β - catenin signaling pathway[1][2].
CAS Number
[2763260-30-4]
UNSPSC
12352005
Target
Molecular Glues; β-catenin
Type
Reference compound
Related Pathways
PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nrx-1933.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(F)(F)F)NC1=O)NC2=CC=CC(C3=NNN=N3)=C2
Molecular Formula
C14H9F3N6O2
Molecular Weight
350.26
References & Citations
[1]Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10 (1) :1402. |[2]Hu Y, et al. Molecular glue degrader for tumor treatment. Front Oncol. 2024 Dec 12;14:1512666.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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