PF-07265807

• Description:

  PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer[1].

• UNSPSC:

  12352005

• Target:

  C-Met/HGFR; TAM Receptor

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tam-met-in-1.html

• Purity:

  97.13

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  OC[C@@H](C)NC1=NNC2=NC=CC(OC3=C(C=C(C=C3)NC(C(C(N4C5=CC=C(C=C5)F)=O)=CN(C(C)C)C4=O)=O)F)=C12

• Molecular Formula:

  C29H27F2N7O5

• Molecular Weight:

  591.57

• References & Citations:

  [1]Ronald Jay Hinklin, et al. PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES. WO2020047184A1 (example 1) .

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  Axl; Mer; Tyro3

• CAS Number:

  [2412356-57-9]