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PF-00277343

CAT: 0804-HY-118978Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118978Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models[1].
CAS Number
332926-04-2
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/pf-00277343.html
Solubility
10 mM in DMSO
Smiles
O=C(N(N=C1)C2=CC(C)=C(C(C)=C2)OC3=CC=C(C(CC4=CC=C(C=C4)F)=C3)O)NC1=O
Molecular Formula
C24H20FN3O4
Molecular Weight
433.43
References & Citations
[1]Li JJ, et al. Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett. 2010 Jan 1;20 (1) :306-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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