PF-03049423

• Description :

  PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke[1].

• CAS Number :

  [402955-58-2]

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-03049423.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3.[xHCl]

• Molecular Formula :

  C24H32N6O4.xHCl

• References & Citations :

  [1]Menniti FS, et al. Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. J Pharmacol Exp Ther. 2009 Dec;331 (3) :842-50.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  PDE5