PF-06424439

• Description:

  PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM[1]. PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate[2].

• UNSPSC:

  12352005

• Target:

  Acyltransferase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-06424439.html

• Purity:

  99.89

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C([C@H]1CN(C2=CC=C3C(NC(C4(N5N=CC(Cl)=C5)CC4)=N3)=N2)CCC1)N6CCCC6

• Molecular Formula:

  C22H26ClN7O

• Molecular Weight:

  439.94

• References & Citations:

  [1]Futatsugi K, et al. Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) . J Med Chem. 2015 Sep 24;58 (18) :7173-85.|[2]Pabst B, et al. Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) . Biochemistry. 2018 Dec 26;57 (51) :6997-7010.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  BioRxiv. 2023 Jul 3.|bioRxiv. 2025 Jul 21.|bioRxiv. 2025 Mar 11:2025.02.18.638929.|Cell Death Dis. 2025 Oct 7;16 (1) :715.|Dev Comp Immunol. 2021 Nov:124:104197.|FASEB J. 2025 Nov 30;39 (22) :e71249.|Int J Biol Macromol. 2024 Dec;282 (Pt 5) :137235.|Nat Commun. 2024 Sep 27;15 (1) :8273.|Protein Cell. 2025 Nov 19:pwaf101.|Research Square Preprint. 2024 Feb 12.|Theranostics. 2024 Jun 1;14 (9) :3470-3485.|Adv Sci (Weinh) . 2025 May 14:e2406150.|Anal Chem. 2025 Jul 22;97 (28) :15393-15401.|Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Aug 22;1870 (8) :159683.|Int Immunopharmacol. 2024 Jun 24:138:112518.|J Biol Chem. 2024 Apr;300 (4) :107168.|J Dairy Sci. 2022 Apr;105 (4) :3588-3600.|J Dairy Sci. 2024 Jun 6:S0022-0302 (24) 00897-X.|J Virol. 2022 Jan 26;96 (2) :e0147321.|Mol Metab. 2024 Jun:84:101953.

• CAS Number:

  [1469284-78-3]