PF-04880594

CAT: 0804-HY-13810Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13810Size:1 Each
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Description
PF-04880594 is a potent and selective RAF inhibitor. PF-04880594 inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 shows antitumor activity[1].
CAS Number
[1111636-35-1]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-04880594.html
Solubility
10 mM in DMSO
Smiles
N#CCCNC1=NC=CC(C2=CN(CC(F)F)N=C2C3=CN=C(NC=C4)C4=C3)=N1
Molecular Formula
C19H16F2N8
Molecular Weight
394.38
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Torti VR, et al. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. Mol Cancer Ther. 2012 Oct;11 (10) :2274-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; C-Raf

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