PF-04880594

• Description :

  PF-04880594 is a potent and selective RAF inhibitor. PF-04880594 inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 shows antitumor activity[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Raf

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pf-04880594.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CCCNC1=NC=CC(C2=CN(CC(F)F)N=C2C3=CN=C(NC=C4)C4=C3)=N1

• Molecular Formula :

  C19H16F2N8

• Molecular Weight :

  394.38

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

• References & Citations :

  [1]Torti VR, et al. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. Mol Cancer Ther. 2012 Oct;11 (10) :2274-83.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  B-Raf; C-Raf

• CAS Number :

  [1111636-35-1]