SD 0006

• Description:

  SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].

• Product Name Alternative:

  SD-06

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  Autophagy; MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/SD-06.html

• Concentration:

  10mM

• Purity:

  98.22

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  OCC (N1CCC (CC1) C2=NNC (C3=CC=C (C=C3) Cl) =C2C4=NC=NC=C4) =O

• Molecular Formula:

  C20H20ClN5O2

• Molecular Weight:

  397.86

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84 (1) :42-60.|[2]Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2634-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  271576-80-8