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CCG-224406

CAT: 0804-HY-123254Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123254Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCG-224406 is a selective G protein-coupled receptor kinase 2 (GRK2) inhibitor with the IC50 values of 13 nM, greater than 700-fold selectivity over other GRK subfamilies, and no inhibition of ROCK1. CCG-224406 can be used for study of heart failure[1].
CAS Number
[1870843-22-3]
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ccg-224406.html
Smiles
O=C(C1=C(C)NC(NC1C2=CC=C(F)C(C(NCC3=C(OC)C=CC=C3OC)=O)=C2)=O)NC4=CC5=C(NN=C5)C=C4
Molecular Formula
C29H27FN6O5
Molecular Weight
558.56
References & Citations
[1]Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016;59 (8) :3793-3807.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2

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