CCG-224406

• Description:

  CCG-224406 is a selective G protein-coupled receptor kinase 2 (GRK2) inhibitor with the IC50 values of 13 nM, greater than 700-fold selectivity over other GRK subfamilies, and no inhibition of ROCK1. CCG-224406 can be used for study of heart failure[1].

• UNSPSC:

  12352005

• Target:

  G Protein-coupled Receptor Kinase (GRK)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ccg-224406.html

• Smiles:

  O=C (C1=C (C) NC (NC1C2=CC=C (F) C (C (NCC3=C (OC) C=CC=C3OC) =O) =C2) =O) NC4=CC5=C (NN=C5) C=C4

• Molecular Formula:

  C29H27FN6O5

• Molecular Weight:

  558.56

• References & Citations:

  [1]Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016;59 (8) :3793-3807.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GRK2

• CAS Number:

  1870843-22-3