CCG-273463

• Description :

  CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].

• CAS Number :

  [2750413-99-9]

• UNSPSC :

  12352005

• Target :

  G Protein-coupled Receptor Kinase (GRK)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ccg-273463.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(NC(CBr)=O)=C(N3)C)C)C(N[C@H](C)C4=CC=CC=C4)=O

• Molecular Formula :

  C26H25BrN4O3

• Molecular Weight :

  521.41

• References & Citations :

  [1]Rachel A Rowlands, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64 (1) :566-585.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported