ERα degrader-2

CAT:

804-HY-132194-02

Size:

10 mg

Price:

Ask

For price, please contact [email protected]

CAS Number: 2235396-63-9
UNSPSC Description: ERα degrader-2 is a selective estrogen receptor degrader (SERD) with potent binding affinity with ERα (IC50=17.1 nM), good degradation efficacy (EC50=0.3 nM). ERα degrader-2 exhibits favorable pharmacokinetic properties and excellent agentgability, can be used for HER+ breast cancer research[1].
Target Antigen: Estrogen Receptor/ERR
Type: Reference compound
Related Pathways: Vitamin D Related/Nuclear Receptor
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/erα-degrader-2.html
Purity: 99.71
Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;adjust pH to 10 with NaOH;heat to 60°C)
Smiles: CC(C)(F)CN1[C@@](C2=C(C=C(C3=CC=C(C=C3)C(O)=O)C=C2F)F)([H])C4=C(C[C@H]1C)C5=CC=CC=C5N4
Molecular Weight: 492.53
References & Citations: [1]Xiaomeng Zhang, et al. Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer. J Med Chem
Shipping Conditions: Room Temperature
Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
Clinical Information: No Development Reported