MK-0752 (sodium)

MK-0752 (sodium)

• CAS Number: 656810-87-6
• UNSPSC Description: MK-0752 sodium is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 sodium crosses the blood-brain barrier. MK-0752 sodium reduces newly generated CNS Aβ in vivo[1][2].
• Target Antigen: γ-secretase
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Stem Cell/Wnt
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/mk-0752-sodium.html
• Smiles: O=C(CC[C@H]1CC[C@@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1)O[Na]
• Molecular Weight: 464.89
• References & Citations: [1]Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750.|[2]Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 4