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MK-0952 (sodium)

CAT: 0804-HY-11071Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-11071Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-0952 sodium is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 sodium has the potential for Alzheimer’s disease study[1][2].
CAS Number
934995-88-7
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mk-0952-sodium.html
Smiles
O=C([C@H]1[C@H](C2=CC=C(C3=CC=CC(N4C=C(C(NC5CC5)=O)C(C6=C4N=CC=C6)=O)=C3)C=C2F)C1)O[Na]
Molecular Formula
C28H21FN3NaO4
Molecular Weight
505.47
References & Citations
[1]Michel Gallant, et al. Discovery of MK-0952, a Selective PDE4 Inhibitor for the Treatment of Long-Term Memory Loss and Mild Cognitive Impairment. Epub 2010 Sep 21.|[2]Tingting Pan, et al. Dual Functional Cholinesterase and PDE4D Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis and Evaluation of tacrine-pyrazolo[3,4-b]pyridine Hybrids. Behav Brain Res. 2016 Apr 15;303:26-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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