MK-886 (sodium salt)

MK-886 (sodium salt)

• CAS Number: 118427-55-7
• UNSPSC Description: MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].
• Target Antigen: Apoptosis; FLAP; Leukotriene Receptor; PPAR
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mk-886-sodium-salt.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(C)(CC1=C(C2=C(N1CC3=CC=C(C=C3)Cl)C=CC(C(C)C)=C2)SC(C)(C)C)C)O[Na]
• Molecular Weight: 494.06
• References & Citations: [1]Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15.|[2]Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64.|[3]Mancini JA, et al. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported