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T-518

CAT: 0804-HY-161307-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161307-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM) . T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy[1][2].
CAS Number
2276680-91-0
UNSPSC
12352005
Target
HDAC; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t-518.html
Purity
98.40
Solubility
10 mM in DMSO
Smiles
O=C(C(F)(F)C(F)(F)F)N[C@H]1[C@H](N2CC3=NC=C(C4=NN=C(C(F)F)O4)C=C3C2=O)CCCC1
Molecular Formula
C19H16F7N5O3
Molecular Weight
495.35
References & Citations
[1]Onishi T, et al. A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice. Sci Rep. 2021 Jul 29;11 (1) :15423. |[2]König B, et al. 2- (Difluoromethyl) -1, 3, 4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation?[J]. ACS Pharmacology & Translational Science, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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