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DD202-114

CAT: 0804-HY-163996-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163996-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DD202-114 is a potent and selective GLP1R agonist. DD202-114 inhibits hERG with an IC50 of 15.9 μM. DD202-114 exhibits strong CYP2C8 inhibition with an IC50 of 0.22 μM. DD202-114 promotes cAMP accumulation. DD202-114 reduces blood glucose levels and food intake. DD202-114 has the potential to be used in the study of type 2 diabetes mellitus (T2DM) and obesity[1][2].
CAS Number
2886728-09-0
UNSPSC
12352005
Target
Cytochrome P450; GLP Receptor; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dd202-114.html
Purity
98.47
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C(N(C(CN3CCC(C4=NC(OCC5=C(C=C(C=C5)C6COC6)F)=CC=C4)CC3)=N2)C[C@@H]7CCO7)=C1)O
Molecular Formula
C33H35FN4O5
Molecular Weight
586.65
References & Citations
[1]Zhang Z, et al. Design and Evaluation of 3-Phenyloxetane Derivative Agonists of the Glucagon-Like Peptide-1 Receptor. J Med Chem. 2024 Sep 12;67 (17) :14820-14839.|[2]Dong G, et al. Discovery and Evaluation of DA-302168S as an Efficacious Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist. J Med Chem. 2025 May 8;68 (9) :9555-9583.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2

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