Anticancer agent 114

• Description :

  Anticancer agent 114 is a potent and orally active dipeptide boronic acid ester proteasome inhibitor with an IC50 value of 2.2 nM. Anticancer agent 114 has antiproliferative activity against the RPMI-8226 cells. Anticancer agent 114 can be used in research of multiple myeloma[1].

• UNSPSC :

  12352005

• Target :

  Proteasome

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-114.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C[C@@H](B1OC2C3OC(C2(O1)C)CC3C(O)=O)NC(C(NC(C4=C(C=CC(C(F)(F)F)=C4)C(F)(F)F)=O)CC5CC5)=O)C

• Molecular Formula :

  C28H33BF6N2O7

• Molecular Weight :

  634.37

• References & Citations :

  [1]Wang X, et, al. Design and discovery of novel dipeptide boronic acid ester proteasome inhibitors, an oral slowly-released prodrug for the treatment of multiple myeloma. Eur J Med Chem. 2023 Mar 15;250:115187.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [9007-83-4]