TAS-114

• Description :

  TAS-114 is an orally active dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine[1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tas-114.html

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=S(CCCOCN(C(N1)=O)C=CC1=O)(N[C@@H](C2=CC=CC(OC3CCCC3)=C2)C)=O

• Molecular Formula :

  C21H29N3O6S

• Molecular Weight :

  451.54

• References & Citations :

  [1]Yano W, et al. TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. Mol Cancer Ther. 2018 Aug;17 (8) :1683-1693.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1198221-21-4]