Lipid 114

• Description:

  Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. Lipid 114 can be used to generate lipid nanoparticles (LNP) to deliver siRNA in vitro as well as in vivo. Lipid 114 LNPs encapsulating siRNA that targets IL-1β can reduce IL-1β expression in macrophages. Lipid 114 LNPs encapsulating siRNA that targets IL-1β also reduces hepatic and renal expression of IL-1β, as well as decreasing hepatic inflammation in mouse model with LPS-induced acute liver failure[1].

• UNSPSC:

  12352211

• Target:

  Liposome

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CCCCCCCCCCCCCCOC(CCN(CCCNCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O

• Molecular Formula:

  C95H186N4O10

• Molecular Weight:

  1544.51

• References & Citations:

  [1]Feng Ding, et al. Identification of a potent ionizable lipid for efficient macrophage transfection and systemic anti-interleukin-1β siRNA delivery against acute liver failure. 2021 RSC.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  No Development Reported