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GSK-114

CAT: 0804-HY-117658-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117658-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM) . GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 μM) . Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue[1].
CAS Number
1301761-96-5
Product Name Alternative
(Z)-Mutagenic Impurity of Tenofovir Disoproxil, BMS-387032, Mutagenic Impurity of Tenofovir Disoproxil (Standard); Tenofovir Impurity 2 (Standard)
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk-114.html
Purity
99.52
Solubility
DMSO : 5.95 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(NC)(C1=CC=C(N(C)C)C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1)=O
Molecular Formula
C19H23N5O4S
Molecular Weight
417.48
Precautions
H315, H319
References & Citations
[1]Lawhorn BG, et al. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorg Med Chem Lett. 2016;26 (14) :3355-3358. |[2]Asquith CRM, et al. New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K) . Molecules. 2020;25 (7) :1697. Published 2020 Apr 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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