Acetaminophen

• Description :

  Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model[5].

• Product Name Alternative :

  Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Bacterial; COX; Endogenous Metabolite; Ferroptosis; Histone Acetyltransferase; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/acetaminophen.html

• Purity :

  99.98

• Solubility :

  DMSO : 250 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

• Smiles :

  O=C(C)NC1=CC=C(O)C=C1

• Molecular Formula :

  C8H9NO2

• Molecular Weight :

  151.16

• Precautions :

  H302

• References & Citations :

  [1]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[2]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[3]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[4]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.|[5]An Y, et al., Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. Int Immunopharmacol. 2023 May;118:110029.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  COX-1; COX-2

• Citation 01 :

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• CAS Number :

  [103-90-2]