Acetaminophen

• UNSPSC Description:

  Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model[5].

• Target Antigen:

  Bacterial; COX; Endogenous Metabolite; Ferroptosis; Histone Acetyltransferase; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/acetaminophen.html

• Purity:

  99.98

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic)

• Smiles:

  O=C(C)NC1=CC=C(O)C=C1

• Molecular Weight:

  151.16

• References & Citations:

  [1]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.|[2]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[3]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[4]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.|[5]An Y, et al., Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. Int Immunopharmacol. 2023 May;118:110029.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Clinical Information:

  Launched

• CAS Number:

  103-90-2