Acetaminophen-d3

• Description:

  Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

• Product Name Alternative:

  Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335, H401

• Target:

  COX; Endogenous Metabolite; Histone Acetyltransferase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Purity:

  99.0

• Solubility:

  10 mM in DMSO|DMSO : 250mg/mL (ultrasonic) |H2O : 10mg/mL (ultrasonic)

• Smiles:

  O=C (NC1=CC=C (O) C=C1) C ([2H]) ([2H]) [2H]

• Molecular Formula:

  C8H6D3NO2

• Molecular Weight:

  154.18

• Precautions:

  H302, H315, H319, H335, H401

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  60902-28-5