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Acetaminophen-d3

CAT: 0804-HY-66005S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-66005S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
CAS Number
60902-28-5
Product Name Alternative
Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H401
Target
COX; Endogenous Metabolite; Histone Acetyltransferase
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Purity
99.0
Solubility
10 mM in DMSO|DMSO : 250mg/mL (ultrasonic) |H2O : 10mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(O)C=C1)C([2H])([2H])[2H]
Molecular Formula
C8H6D3NO2
Molecular Weight
154.18
Precautions
H302, H315, H319, H335, H401
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TRC-A161221-2.5MGAcetaminophen-d3
CS-P-00340Acetaminophen-d3 Glucuronide
AR-A01165-01Acetaminophen-d3 mercapturate
TRC-M226052-50MG3-Methoxy Acetaminophen-d3
TRC-A161227-1MG4-Acetaminophen-d3 Sulfate
AR-A05361-01N-Nitroso Acetaminophen-d3
AR-A01163-01Acetaminophen-d3 Sulphate Potassium Salt
AR-A05359-01Acetaminophen-d3 Glucuronide Sodium Salt
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