Acetaminophen-d5

CAT: 0804-HY-66005S5Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-66005S5Size:1 mg
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Description
Acetaminophen-d5 is deuterated-labeled Acetaminophen (HY-66005) . Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
Product Name Alternative
Paracetamol-d5; 4-Acetamidophenol-d5; 4'-Hydroxyacetanilide-d5
UNSPSC
12352005
Target
COX; Endogenous Metabolite; Histone Acetyltransferase; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC1=C(C([2H])=C(C([2H])=C1[2H])NC(C[2H])=O)[2H]
Molecular Formula
C8H4D5NO2
Molecular Weight
156.19
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-226.|[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90. |[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594. |[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209. |[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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