Acetaminophen-d5

• Description:

  Acetaminophen-d5 is deuterated-labeled Acetaminophen (HY-66005) . Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

• Product Name Alternative:

  Paracetamol-d5; 4-Acetamidophenol-d5; 4'-Hydroxyacetanilide-d5

• UNSPSC:

  12352005

• Target:

  COX; Endogenous Metabolite; Histone Acetyltransferase; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

• Field of Research:

  Cancer; Inflammation/Immunology

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C (C ([2H]) =C (C ([2H]) =C1[2H]) NC (C[2H]) =O) [2H]

• Molecular Formula:

  C8H4D5NO2

• Molecular Weight:

  156.19

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-226.|[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90. |[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594. |[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209. |[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported