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Acetaminophen-d4

CAT: 0804-HY-66005S-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-66005S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acetaminophen-d4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
CAS Number
[64315-36-2]
Product Name Alternative
Paracetamol-d4; 4-Acetamidophenol-d4; 4'-Hydroxyacetanilide-d4
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
COX; Endogenous Metabolite; Histone Acetyltransferase
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Purity
99.60
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=C(C([2H])=C(C([2H])=C1[2H])NC(C)=O)[2H]
Molecular Formula
C8H5D4NO2
Molecular Weight
155.19
Precautions
H302, H312, H332
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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DE2089Acetaminophen-D4
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