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Acetaminophen glucuronide

CAT: 0804-HY-113083Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113083Size:5 mg
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Description
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen[2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4].
CAS Number
16110-10-4
Product Name Alternative
APAP-glu
UNSPSC
12352005
Hazard Statement
H302
Target
Drug Metabolite; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/acetaminophen-glucuronide.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC=C(C=C2)NC(C)=O)=O
Molecular Formula
C14H17NO8
Molecular Weight
327.29
Precautions
H302
References & Citations
[1]Carolina I Ghanem, et al. Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats. J Pharmacol Exp Ther. 2005 Dec;315 (3) :987-95.|[2]Liudmila L Mazaleuskaya, et al. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25 (8) :416-26.|[3]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[4]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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