Acetaminophen glucuronide

• Description:

  Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) [1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4].

• Product Name Alternative:

  APAP-glu

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Drug Metabolite; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/acetaminophen-glucuronide.html

• Purity:

  99.9

• Solubility:

  10 mM in DMSO

• Smiles:

  OC ([C@H] ([C@H] ([C@@H] ([C@H]1O) O) O) O[C@H]1OC2=CC=C (C=C2) NC (C) =O) =O

• Molecular Formula:

  C14H17NO8

• Molecular Weight:

  327.29

• Precautions:

  H302

• References & Citations:

  [1]Carolina I Ghanem, et al. Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats. J Pharmacol Exp Ther. 2005 Dec;315 (3) :987-95.|[2]Liudmila L Mazaleuskaya, et al. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25 (8) :416-26.|[3]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[4]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  16110-10-4