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Microtubule destabilizing agent-2

CAT: 0804-HY-159891Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159891Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective antitumor compound targeting microtubule protein. Microtubule destabilizing agent-2 destabilizes microtubule proteins and inhibits microtubule polymers. Microtubule destabilizing agent-2 arrests the G0/G1 phase in human tumor cells. Microtubule destabilizing agent-2 induces Apoptosis by activating the cascade pathway of caspases. Microtubule destabilizing agent-2 has anti-inflammatory activity, as inhibiting TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 reduces tumors growth in xenograft mice[1].
UNSPSC
12352005
Target
Apoptosis; Caspase; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-destabilizing-agent-2.html
Smiles
OC1=C(C2=C(C[C@]([H])(CCC3=C4C=CC(OCC5=CC=CC=C5)=C3)[C@@]24[H])C=C1OC)OC
Molecular Formula
C26H26O4
Molecular Weight
402.48
References & Citations
[1]Fatima, et al. 5H-benzo[c]fluorene derivative exhibits antiproliferative activity via microtubule destabilization. Bioorganic chemistry, 2024, 153:107891.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3

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