Microtubule destabilizing agent-2

• UNSPSC Description:

  Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective antitumor compound targeting microtubule protein. Microtubule destabilizing agent-2 destabilizes microtubule proteins and inhibits microtubule polymers. Microtubule destabilizing agent-2 arrests the G0/G1 phase in human tumor cells. Microtubule destabilizing agent-2 induces Apoptosis by activating the cascade pathway of caspases. Microtubule destabilizing agent-2 has anti-inflammatory activity, as inhibiting TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 reduces tumors growth in xenograft mice[1].

• Target Antigen:

  Apoptosis; Caspase; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/microtubule-destabilizing-agent-2.html

• Smiles:

  OC1=C(C2=C(C[C@]([H])(CCC3=C4C=CC(OCC5=CC=CC=C5)=C3)[C@@]24[H])C=C1OC)OC

• Molecular Weight:

  402.48

• References & Citations:

  [1]Fatima, et al. 5H-benzo[c]fluorene derivative exhibits antiproliferative activity via microtubule destabilization. Bioorganic chemistry, 2024, 153:107891.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported