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Microtubule destabilizing agent-1

CAT: 0804-HY-139981Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139981Size:1 Each
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Description
Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity[1].
CAS Number
2850370-28-2
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-destabilizing-agent-1.html
Solubility
10 mM in DMSO
Smiles
CN(C1=NC(C)=NC2=CC=CC=C12)C3=CC(OC(C(C)C)C(NO)=O)=C(OC)C=C3
Molecular Formula
C22H26N4O4
Molecular Weight
410.47
References & Citations
[1]Linyu Yang, et al. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem. 2021 Oct 28;64 (20) :15379-15401.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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