Apoptotic agent-2

• Description :

  Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcl-2 Family; Caspase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/apoptotic-agent-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(/N=N/C2=CC=C(Cl)C=C2)SC(N/N=C3C4=C(C5=NC6=CC=CC=C6N=C5\3)C=CC=C4)=N1

• Molecular Formula :

  C25H16ClN7S

• Molecular Weight :

  481.96

• References & Citations :

  [1]Fayed EA, et al. In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies. Bioorg Chem. 2020 Jul;100:103951.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bax; Bcl-2; Caspase 3

• CAS Number :

  [2482310-18-7]