Microtubule stabilizing agent-1

• UNSPSC Description:

  Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy[1].

• Target Antigen:

  Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/microtubule-stabilizing-agent-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1C(C2(C)C)=C([C@H](C[C@]2([C@H](C3[C@](C)(C1=O)[C@H](C[C@@H]4[C@@]3(OC(C)=O)CO4)O)OC(C5=CC=CC=C5)=O)O)OC([C@@H]([C@H](C6=CC=CC=C6)NC(/C=C/C(C)(C)C)=O)O)=O)C

• Molecular Weight:

  817.92

• References & Citations:

  [1]Yuntao Ma, et al. Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency. Eur J Med Chem. 2023 Nov 5;259:115668.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported