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Microtubule stabilizing agent-1

CAT: 0804-HY-155647Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155647Size:1 Each
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Description
Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy[1].
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-stabilizing-agent-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1C(C2(C)C)=C([C@H](C[C@]2([C@H](C3[C@](C)(C1=O)[C@H](C[C@@H]4[C@@]3(OC(C)=O)CO4)O)OC(C5=CC=CC=C5)=O)O)OC([C@@H]([C@H](C6=CC=CC=C6)NC(/C=C/C(C)(C)C)=O)O)=O)C
Molecular Formula
C45H55NO13
Molecular Weight
817.92
References & Citations
[1]Yuntao Ma, et al. Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency. Eur J Med Chem. 2023 Nov 5;259:115668.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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