MK2-IN-5 (acetate)

MK2-IN-5 (acetate)

• UNSPSC Description: MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation[1][2][3].
• Target Antigen: ERK; HSP; JNK; MAPKAPK2 (MK2); p38 MAPK
• Type: Peptides
• Related Pathways: Cell Cycle/DNA Damage;MAPK/ERK Pathway;Metabolic Enzyme/Protease;Stem Cell/Wnt
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/mk2-in-5-acetate.html
• Purity: 98.46
• Solubility: H2O : 80 mg/mL (ultrasonic)
• Smiles: O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N.CC(O)=O.[x]
• Molecular Weight: 1396.68 (free base)
• References & Citations: [1]Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480.|[2]Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600.|[3]Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
• Clinical Information: No Development Reported