MK2-IN-1

• UNSPSC Description:

  MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein[1][2].

• Target Antigen:

  HSP; MAPKAPK2 (MK2)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;MAPK/ERK Pathway;Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MK2-IN-1.html

• Purity:

  99.04

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C(C2=CC=C(Cl)C=C2)O1)N(C3=CC=C(N4CCNCC4)C=C3)CC5=NC=CC=C5

• Molecular Weight:

  472.97

• References & Citations:

  [1]Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.|[2]Yan Zhang, et al. MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal. Cell Rep. 2021 Nov 2;37(5):109949.Cell Rep. 2021 Nov 2;37(5):109949.|J Pharmacol Exp Ther. 2019 Aug;370(2):219-230.|Cell Death Dis. 2021 Oct 23;12(11):994.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1314118-92-7