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MK2-IN-6

CAT: 0804-HY-162700Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162700Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK2-IN-6 (Compound 11) is a potent and selective irreversible MK2 inhibitor with an IC50 value of 2.3 nM. MK2-IN-6 inhibits MK2 kinase activity, achieving prolonged MK2 signaling suppression and reducing pathological inflammatory cytokines in macrophages. MK2-IN-6 inhibits the M2-like protumor phenotype of macrophages both in vitro and in vivo, which is proming for research of colorectal cancer[1].
UNSPSC
12352211
Target
MAPKAPK2 (MK2)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mk2-in-6.html
Smiles
O=C(C=C)NC1=C(OC(F)(F)F)C=CC(C2=NC=CC(C3=CC(C(NCC4)=O)=C4N3)=C2)=C1
Molecular Formula
C22H17F3N4O3
Molecular Weight
442.39
References & Citations
[1]Wang D, et al. Remodeling tumor-associated macrophage for anti-cancer effects by rational design of irreversible inhibition of mitogen-activated protein kinase-activated protein kinase 2[J]. MedComm (2020) . 2024 Jul 10;5 (7) :e634.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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