MK2-IN-6

• UNSPSC Description:

  MK2-IN-6 (Compound 11) is a potent and selective irreversible MK2 inhibitor with an IC50 value of 2.3 nM. MK2-IN-6 inhibits MK2 kinase activity, achieving prolonged MK2 signaling suppression and reducing pathological inflammatory cytokines in macrophages. MK2-IN-6 inhibits the M2-like protumor phenotype of macrophages both in vitro and in vivo, which is proming for research of colorectal cancer[1].

• Target Antigen:

  MAPKAPK2 (MK2)

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mk2-in-6.html

• Smiles:

  O=C(C=C)NC1=C(OC(F)(F)F)C=CC(C2=NC=CC(C3=CC(C(NCC4)=O)=C4N3)=C2)=C1

• Molecular Weight:

  442.39

• References & Citations:

  [1]Wang D, et al. Remodeling tumor-associated macrophage for anti-cancer effects by rational design of irreversible inhibition of mitogen-activated protein kinase-activated protein kinase 2[J]. MedComm (2020). 2024 Jul 10;5(7):e634.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported