MK2-IN-6

MK2-IN-6

• UNSPSC Description: MK2-IN-6 (Compound 11) is a potent and selective irreversible MK2 inhibitor with an IC50 value of 2.3 nM. MK2-IN-6 inhibits MK2 kinase activity, achieving prolonged MK2 signaling suppression and reducing pathological inflammatory cytokines in macrophages. MK2-IN-6 inhibits the M2-like protumor phenotype of macrophages both in vitro and in vivo, which is proming for research of colorectal cancer[1].
• Target Antigen: MAPKAPK2 (MK2)
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mk2-in-6.html
• Smiles: O=C(C=C)NC1=C(OC(F)(F)F)C=CC(C2=NC=CC(C3=CC(C(NCC4)=O)=C4N3)=C2)=C1
• Molecular Weight: 442.39
• References & Citations: [1]Wang D, et al. Remodeling tumor-associated macrophage for anti-cancer effects by rational design of irreversible inhibition of mitogen-activated protein kinase-activated protein kinase 2[J]. MedComm (2020). 2024 Jul 10;5(7):e634.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported