MK2-IN-3 (hydrate)

MK2-IN-3 (hydrate)

• CAS Number: 1186648-22-5
• UNSPSC Description: MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1].
• Target Antigen: MAPKAPK2 (MK2)
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mk-2-inhibitor-iii.html
• Purity: 99.0
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.O
• Molecular Weight: 358.39
• References & Citations: [1]Anderson DR, et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported