Products for Research Use Only
RegisterLogin

MK2-IN-3 (hydrate)

CAT: 0804-HY-112457-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-112457-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1 (IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1].
CAS Number
1186648-22-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MAPKAPK2 (MK2)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mk-2-inhibitor-iii.html
Purity
99.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.O
Molecular Formula
C21H18N4O2
Molecular Weight
358.39
Precautions
H315, H319
References & Citations
[1]Anderson DR, et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) . J Med Chem. 2007 May 31;50 (11) :2647-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-131249-01MK2-IN-3
HY-P10072MK2-IN-5
HY-12834-01MK2-IN-1
HY-162700MK2-IN-6
HY-179237MK2-IN-8
HY-169513MK2-IN-7
HY-147283MK2-IN-4
HY-12834A-01MK2-IN-1 (hydrochloride)
HY-P10072A-01MK2-IN-5 (acetate)
HY-168841P38α-MK2-IN-1

Alternative Products

CatalogName
GTR19176647-01MK2-IN-3 hydrate
TB015983-Isomangostin hydrate
426318-013-Methoxyphenylglyoxal hydrate
sc-2608513-Bromophenylglyoxal hydrate
sc-5070263-Chlorophenylglyoxal hydrate
426663-013-Sulfobenzaldehyde Hydrate
OR16283-Acetamidophenylglyoxal hydrate
OR16293-Benzyloxyphenylglyoxal hydrate
PC10535-013-fluorophenylglyoxal hydrate
M13799-01MSX-3 hydrate

Popular Products