MK2-IN-8

• Description :

  MK2-IN-8 (Compound 42) is a covalent MK2 kinase inhibitor. MK2-IN-8 forms a unique covalent bond with the catalytic lysine, thereby demonstrating that the fluorosulfonate can effectively target the catalytic lysine in kinases.

• UNSPSC :

  12352005

• Target :

  MAPKAPK2 (MK2)

• Related Pathways :

  MAPK/ERK Pathway

• Field of Research :

  Others

• Smiles :

  O=C(C1=CC=C(C2=CC(OS(=O)(F)=O)=C(Cl)C=C2)O1)N(CC3=NC=CC=C3)C4=CC=C(N5CCNCC5)C=C4

• Molecular Formula :

  C27H24ClFN4O5S

• Molecular Weight :

  571.02

• References & Citations :

  [1]Hillebrand L, et al. A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2. RSC Med Chem. 2025 Aug 1;16 (10) :4906-4919.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported