KR-33493

• Description :

  KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1) .

• CAS Number :

  [1021497-97-1]

• UNSPSC :

  12352005

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/KR-33494.html

• Concentration :

  10mM

• Purity :

  99.94

• Solubility :

  DMSO : ≥ 31 mg/mL

• Smiles :

  OC(C1=NN(CCC2=CC=CC=C2)C=C1NC(CSC3=CC=C(Br)C=C3)=O)=O

• Molecular Formula :

  C20H18BrN3O3S

• Molecular Weight :

  460.34

• References & Citations :

  [1]Jeong JW, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016 Nov;81:387-396.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TNFRSF6/Fas/CD95