APS6-45

• Description :

  APS6-45 is an orally active tumor-calibrated inhibitor (TCI) . APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity[1].

• CAS Number :

  [2188236-41-9]

• UNSPSC :

  12352005

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/aps6-45.html

• Purity :

  99.58

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=NC=CC(OC2=CC=C(C=C2)NC(NC3=CC(C(F)(C(F)(F)F)C(F)(F)F)=CC=C3F)=O)=C1)NC

• Molecular Formula :

  C23H16F8N4O3

• Molecular Weight :

  548.39

• References & Citations :

  [1]Sonoshita M, et, al. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol. 2018 Mar;14 (3) :291-298.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported